正文
获取原文件references/kegg.md
Base URL
https://rest.kegg.jp
Auth
No API key required. Free for academic use. Commercial use requires license.
Important: KEGG returns tab-delimited text and flat-file format, NOT JSON.
Key Operations (URL-path-based, no query parameters)
| URL Pattern | Description |
|---|---|
/list/{database} |
List all entries |
/list/{database}/{organism} |
List entries for organism |
/get/{dbentries} |
Get entry data (flat-file) |
/get/{dbentries}/image |
Pathway image (PNG) |
/get/{dbentries}/kgml |
Pathway as KGML XML |
/find/{database}/{query} |
Search by keyword |
/find/{database}/{query}/formula |
Search by molecular formula |
/find/{database}/{value}/exact_mass |
Search by exact mass |
/link/{target_db}/{source_db} |
Find linked entries between databases |
/link/{target_db}/{dbentries} |
Links for specific IDs |
/conv/{target_db}/{dbentries} |
Cross-reference ID conversion |
/ddi/{dbentries} |
Drug-drug interactions |
Database Codes
| Code | Database | Example ID |
|---|---|---|
pathway |
Pathways | hsa00010 |
compound |
Compounds | C00001 |
drug |
Drugs | D00001 |
enzyme |
Enzymes | ec:1.1.1.1 |
genes/hsa |
Genes | hsa:10458 |
disease |
Diseases | H00001 |
reaction |
Reactions | R00001 |
ko |
KO orthologs | K00001 |
Example Calls
# List human pathways
https://rest.kegg.jp/list/pathway/hsa
# Get pathway entry
https://rest.kegg.jp/get/hsa00010
# Search compounds by name
https://rest.kegg.jp/find/compound/aspirin
# Search by molecular formula
https://rest.kegg.jp/find/compound/C9H8O4/formula
# Find pathways for a gene
https://rest.kegg.jp/link/pathway/hsa:10458
# Find diseases for a gene
https://rest.kegg.jp/link/disease/hsa:672
# Convert KEGG to PubChem IDs
https://rest.kegg.jp/conv/pubchem/C00001
# Get multiple entries (max 10, joined with +)
https://rest.kegg.jp/get/C00001+C00002+C00003
# Drug-drug interactions
https://rest.kegg.jp/ddi/D00564+D00110
Response Format
Tab-delimited text for list/find/link/conv. Flat-file text for get. No JSON support.
Rate Limits
KEGG requests at most 3 calls per second; pace below that and honor failures. Batch up to 10 IDs per /get with +. May return HTTP 403 if too many requests.
KEGG conv/pubchem/... maps to PubChem Substance IDs (SIDs), not Compound IDs (CIDs). Resolve SID to CID through PubChem before joining compound properties. Official contract: https://www.kegg.jp/kegg/rest/keggapi.html