正文
获取原文件REPORT_TEMPLATE.md
Use this template when creating the initial report file {disease_name}_research_report.md.
# Disease Research Report: {Disease Name}
**Report Generated**: {date}
**Disease Identifiers**: (to be filled)
---
## Executive Summary
(Brief 3-5 sentence overview - fill after all research complete)
---
## 1. Disease Identity & Classification
### Ontology Identifiers
| System | ID | Source |
|--------|-----|--------|
| EFO | | |
| ICD-10 | | |
| UMLS CUI | | |
| SNOMED CT | | |
### Synonyms & Alternative Names
- (list with source)
### Disease Hierarchy
- Parent:
- Subtypes:
**Sources**: (list tools used)
---
## 2. Clinical Presentation
### Phenotypes (HPO)
| HPO ID | Phenotype | Description | Source |
|--------|-----------|-------------|--------|
### Symptoms & Signs
- (list with source)
### Diagnostic Criteria
- (from literature/MedlinePlus)
**Sources**: (list tools used)
---
## 3. Genetic & Molecular Basis
### Associated Genes
| Gene | Score | Ensembl ID | Evidence | Source |
|------|-------|------------|----------|--------|
### GWAS Associations
| SNP | P-value | Odds Ratio | Study | Source |
|-----|---------|------------|-------|--------|
### Pathogenic Variants (ClinVar)
| Variant | Clinical Significance | Condition | Source |
|---------|----------------------|-----------|--------|
**Sources**: (list tools used)
---
## 4. Treatment Landscape
### Approved Drugs
| Drug | ChEMBL ID | Mechanism | Phase | Target | Source |
|------|-----------|-----------|-------|--------|--------|
### Clinical Trials
| NCT ID | Title | Phase | Status | Intervention | Source |
|--------|-------|-------|--------|--------------|--------|
### Treatment Guidelines
- (from literature)
**Sources**: (list tools used)
---
## 5. Biological Pathways & Mechanisms
### Key Pathways
| Pathway | Reactome ID | Genes Involved | Source |
|---------|-------------|----------------|--------|
### Protein-Protein Interactions
- (tissue-specific networks)
### Expression Patterns
| Tissue | Expression Level | Source |
|--------|------------------|--------|
**Sources**: (list tools used)
---
## 6. Epidemiology & Risk Factors
### Prevalence & Incidence
- (from literature)
### Risk Factors
| Factor | Evidence | Source |
|--------|----------|--------|
### GWAS Studies
| Study | Sample Size | Findings | Source |
|-------|-------------|----------|--------|
**Sources**: (list tools used)
---
## 7. Literature & Research Activity
### Publication Trends
- Total publications (5 years):
- Current year:
- Trend:
### Key Publications
| PMID | Title | Year | Citations | Source |
|------|-------|------|-----------|--------|
### Research Institutions
- (from OpenAlex)
**Sources**: (list tools used)
---
## 8. Similar Diseases & Comorbidities
### Similar Diseases
| Disease | Similarity Score | Shared Genes | Source |
|---------|-----------------|--------------|--------|
### Comorbidities
- (from literature/clinical data)
**Sources**: (list tools used)
---
## 9. Cancer-Specific Information (if applicable)
### CIViC Variants
| Gene | Variant | Evidence Level | Clinical Significance | Source |
|------|---------|----------------|----------------------|--------|
### Molecular Profiles
- (biomarkers)
### Targeted Therapies
| Therapy | Target | Evidence | Source |
|---------|--------|----------|--------|
**Sources**: (list tools used)
---
## 10. Drug Safety & Adverse Events
### Drug Warnings
| Drug | Warning Type | Description | Source |
|------|--------------|-------------|--------|
### Clinical Trial Adverse Events
| Trial | Drug | Adverse Event | Frequency | Source |
|-------|------|---------------|-----------|--------|
### FAERS Reports
- (FDA adverse event data)
**Sources**: (list tools used)
---
## References
### Data Sources Used
| Tool | Query | Section |
|------|-------|---------|
### Database Versions
- OpenTargets: (version/date)
- ClinVar: (version/date)
- GWAS Catalog: (version/date)
Citation Format
Every piece of data MUST include its source. Use these formats:
In Tables
| Gene | Score | Source |
|------|-------|--------|
| APOE | 0.92 | OpenTargets_get_associated_targets_by_disease_efoId |
| APP | 0.88 | OpenTargets_get_associated_targets_by_disease_efoId |
In Lists
- Memory loss [Source: OpenTargets_get_associated_phenotypes_by_disease_efoId]
- Cognitive decline [Source: MedlinePlus_get_genetics_condition_by_name]
In Prose
The disease affects approximately 6.5 million Americans (Source: PubMed_search_articles,
query: "Alzheimer disease epidemiology").
References Section
At the end of the report, include complete tool usage log:
## References
### Tools Used
| # | Tool | Parameters | Section | Items Retrieved |
|---|------|------------|---------|-----------------|
| 1 | OSL_get_efo_id_by_disease_name | disease="Alzheimer disease" | Identity | 1 |
| 2 | ols_get_efo_term | obo_id="EFO:0000249" | Identity | 1 |
| 3 | OpenTargets_get_associated_targets_by_disease_efoId | efoId="EFO_0000249" | Genetics | 245 |
| ... | ... | ... | ... | ... |
### Data Retrieved Summary
- Total tools used: 45
- Total API calls: 78
- Sections completed: 10/10